I was able to shrinkwrap the .obj surface file I got from Santiago into a solid step file using CREO but the outer surfaces still need to be smoothed out:
image.png
On a side note, I've had bad experiences with Autodesk Simulation CFD (formerly CF Design) mainly because it uses a finite element approach and converges based on element criteria instead of other CFD tools, which use finite difference or finite volume, whose convergence criteria is based on energy balance. The autodesk tool could not correlate a simple cold plate pressure drop experiment without tons of fine tuning and the customer service was poor, so I lost confidence in it. I would trust Fluent, Ansys CFX or FloEFD far more.